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TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Calcium ion (40 Da, Ligand)
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Calmodulin-1 (Cellular component from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)
Electron cryo-microscopy structure of the canonical TRPC4 ion channel
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6g1k
Q-score: 0.426
Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S
eLife (2018) 7 [ Pubmed: 29717981 DOI: doi:10.7554/eLife.36615 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Trpc4 (432 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)